Department Seminars

See the Campus Event Calendar for details about upcoming seminars

Location: UW Biotechnology Center Auditorium

Day and Time:  Fridays from noon to 1 pm central time

Zoom options will be available, although in-person attendance is preferred.

Further details should be available about a week before the seminar.

Note: some events may have a different date and time.

Upcoming Seminars

 

September 22, 2023

Speaker: Casey Taylor, Johns Hopkins University

Title: Clinical decision support for unsolicited genomic results.

Zoom: https://uwmadison.zoom.us/j/92966987717

Poster: Taylor Poster 20230922

Abstract: Given that clinical genomic tests can be initiated outside of the clinical setting (for example, in a research study), from the clinician’s perspective, they can be characterized as “unsolicited,” which brings the challenge of how to determine the value and use of those data in patient care. Dr. Taylor will describe her ongoing research investigating the information and technical requirements for software to enable risk-benefit stratification of clinical decision support (CDS) for unsolicited genomic results (UGR) and the attributes needed for genomic service providers to decide how to prioritize and implement CDS based on UGR. Furthermore, Dr. Taylor is exploring how approaches used for UGR apply for prediction models. The broader impacts of this work are enhancing the productivity and effectiveness of genomic service providers; a greater awareness of how software can be used to support the work of genomic service providers; and an increased ability to implement CDS based upon UGR and prediction models within heterogeneous clinical IT infrastructures.

September 29, 2023

  • Speaker: Hongtu Zhu, University of North Carolina at Chapel Hill
  • Title: Establishing the Causal Genetic Imaging Clinical Pathway for Brain-Related Disorders
  • NOTE – Alternate location: 1345 HSLC
  • Zoom: https://uwmadison.zoom.us/j/93430373918
  • Abstract: Our causal genetic imaging clinical (CGIC) pathway is motivated by the joint analysis of genetic, imaging, and clinical (GIC) data collected in many large-scale biomedical studies, such as the UK Biobank study and the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. We propose a statistical framework based on partially functional linear regression models and varying coefficient models to map CGIC pathway for phenotypes associated with brain-related disorders. We develop a joint model selection, estimation, and inference procedure by embedding imaging data in the reproducing kernel Hilbert space and imposing the penalty for the coefficients of scalar variables. We systematically investigate the theoretical properties of scalar and functional efficient estimators, including non-asymptotic error bound, minimax error bound, and asymptotic normality. We apply the proposed method to the ADNI and UKB datasets to identify important features from several millions of genetic polymorphisms and study the effects of a certain set of informative genetic variants and the hippocampus surface on different clinical variables.

October 6, 2023

Speaker: Claudia Solis-Lemus, Department of Plant Pathology, Affiliate Faculty Biostatistics and Medical Informatics

NOTE – Alternate Location: 1345 HSLC

Zoom: https://uwmadison.zoom.us/j/98553230017

October 13, 2023

Speaker: Solomon Harrar, University of Kentucky

Zoom: https://uwmadison.zoom.us/j/95962287569

October 20

Speaker: Yeonhee Park, Department of Biostatistics and Medical Informatics

Zoom: https://uwmadison.zoom.us/j/93846562499

October 20 (NOTE TIME CHANGE: 3-5 PM)

Special Event – SMPH Collaborate

More Information and Registration: go.wisc.edu/smphcollaborate

October 26 – DeMets Lecture

(NOTE VENUE and TIME CHANGE: HSLC 1335 from 3:30-4:45 pm, followed by a reception in the HSLC Atrium from 4:45-6:00 pm.)

Speaker: Colin Begg, Memorial Sloan Kettering Cancer Center

Zoom: https://uwmadison.zoom.us/j/96250055680

 

October 27

Speaker: Alan Moses, University of Toronto

Zoom: https://uwmadison.zoom.us/j/94818443929

November 3

Speaker: Lu Mao, Biostatistics and Medical Informatics

NOTE: Alternate Location: 1345 HSLC

Zoomhttps://uwmadison.zoom.us/j/94594077790

November 10

Speaker: Dongjun Chung, Ohio State University

Zoom: https://uwmadison.zoom.us/j/97277561800

November 17

Speaker: Christina Leslie, Memorial Sloan-Kettering Cancer Center

Zoom: https://uwmadison.zoom.us/j/99221050493

November 24

  • no seminar (holiday)

December 1

  • Speaker: Felix Elwert, Department of Sociology, Faculty Affiliate Department of Biostatistics and Medical Informatics
  • NOTE: Alternate Location: 1306 HSLC
  • Zoom: https://uwmadison.zoom.us/j/91444087740

December 8

Speakers: Fall 2023 Student Rotation Presentations

Zoom: https://uwmadison.zoom.us/j/99626646579

Completed seminars:

September 8, 2023

Title: Summer 2023 Student Rotation Presentations

Ryan Kassab
Project: Statistical Methods for Analyzing Stepped Wedge Cluster Randomized Trials: A Selective Review
Mentor: SushmitaRoy

Yujia Cai 
Project: Detecting Intron Retention Events in DEAD-Box Helicase 41 Germline Variants
Mentor: SunduzKeles

Tinghui Xu
Project: Using Optimal Transport for Quantile Treatment Effect Estimation
Mentor: MenggangYu

Sierra Strutz
Project: Predicting Ovarian Cancer Using EHR Data
Mentor: Irene Ong

Emma Croxford
Project: Determining Potential Differences in Secretome Cytokine Expression using Linear Discriminant Analysis”
Mentor: RickChappell

Jie Sheng
Project: Evaluating Cell-Cell Interaction (CCI) Scores Using Spatial Transcriptomics Data
Mentor: Huy Dinh

Yuda Liu
Project: Benchmarking Causal Graph Inference Algorithms on Simulated and Real Expression Datasets
Mentor: SushmitaRoy

September 15, 2023

Speaker: Joseph Ibrahim, University of North Carolina at Chapel Hill

Title: The Scale Transformed Power Prior for Time-to-Event Data

Poster: Ibrahim_Poster 20230915

Abstract: In clinical trials, data is often available from a previous trial with a different outcome (i.e., binary vs time-to-event). The power prior proposed by Ibrahim and Chen (2000) does not account for different data types in the context discussed here. To accommodate settings in which the historical data and the current data involve different data types, we develop the partial-borrowing scale transformed power prior (straPP) for several commonly used time-to-event models. The partial-borrowing straPP is developed through rescaling the parameter vector from the historical data to align with that of the new data using a transformation based on the Fisher information matrices from the two data models. We also develop the generalized scale transformed power prior (Gen-straPP) to provide added robustness for the case in which the scaled parameters are not equal. Several real data sets from the Eastern Cooperative Oncology Group are used to motivate the use of the proposed methods. We demonstrate the advantages of the partial-borrowing straPP over other common priors via simulation and real data analyses using the proportional hazards model and the mixture cure rate model.

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