Please join us for this week’s Biostatistics & Medical Informatics seminar on Friday!
Time & Place: Friday, November 13th, 2020 at 12:00 noon.
Link: https://uwmadison.zoom.us/j/97421564201?pwd=WERNY2VPcGFaeDNLdVAwRkt1cks1QT09
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uwmadison.zoom.us
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Meeting ID: 974 2156 4201
Passcode: 553023
(Link will be available on BMI website soon)
Title: Probing the Nuclear Organization via Machine Learning
Presenters: Jian Ma, PhD, from Carnegie Mellon University
Abstract: The chromosomes of the human genome are organized in three-dimensions by compartmentalizing the cell nucleus and different genomic loci also interact with each other. However, the principles underlying such nuclear genome organization and its functional impact remain poorly understood. In this talk, I will introduce some of our recent work in developing machine learning methods by utilizing whole-genome mapping data to study the higher-order genome organization. Our methods reveal the spatial localization of chromosome regions and exploit chromatin interactome patterns within the cell nucleus in different cellular conditions, across mammalian species, and also in single-cell resolution. We hope that these algorithms will provide new insights into the structure and function of nuclear organization in health and disease.
Jian Ma Poster (PDF)